Dose-response analyses in OS cell lines and control cells after compound treatment.

<p>Cells were treated for 24h with compounds A13 (A), H12 (B), or with classical drugs staurosporine (C) and doxorubicin (D), respectively. Cell viability was assessed using CtB assay. Shown is fold change of cell viability normalized to DMSO-treated control for each cell type after incubation with increasing concentrations (μM) of the respective substance for 24h. Data are expressed as mean +/- SD from duplicates of three independent experiments. Differences of means were calculated using multiple t test for all cell lines versus primary hOB and all highly significant differences with #p < 0.001 are indicated by hash key (#). Differences of means to control were calculated for all bars and all were significantly different from control with *p < 0.05 indicated by the lines on top of the bars except those bars that are marked with ns = not significant (p > 0.05).