Paw volume and cartilage degradation scoring of therapeutically treated groups.

<p>(A) Paw volume changes in therapeutically treated rat groups from day 1–43 (values analyzed using RM-ANOVA with Graph Pad prism; "***" indicates significant difference compared to negative control (NC) (P<0.001); "#" indicates significant difference compared to therapeutic positive control (TPC) (### represents P<0.001, ## represents P<0.01 and # represents P<0.05); values represented in Mean ± SEM, n = 12. (B) Cartilage degradation scores from histomorphological sections of therapeutically treated groups; "**" indicates significant difference compared to NC (P<0.01); statistically significant differences between TPC and TT or TE groups indicated as "#" (P<0.05); values represented in Mean ± SEM, n = 6.