Plasma metabolites key to group separation predicted by Random Forest classification.

<p>The top 30 plasma metabolites important for increasing class separation as determined by the Random Forest approach. Bradykinin was seen as most important for class separation, however, smaller peptides also showed class discrimination, such as L-aspartyl-L-phenylalanine, and alanyl-alanine. Energy metabolism, as reflected by the presence of riboflavin as a biomarker, was indicated. Metabolites suggesting multiple organ interactions, i.e. kidney/liver/GI tract/microbiome were indicated (see text).