Representative histomorphological features of esophageal mucosal epithelium in pill-induced esophagitis (A-E) and reflux esophagitis (F).

<p>(A) This case shows abundant intraepithelial eosinophil infiltration with eosinophilic microabscess with > 4 eosinophils found in rows. (B) Mixed infiltration of eosinophils and neutrophils is observed within the squamous epithelium. (C) Note intraepithelial pustules, i.e., bullae with scattered neutrophils. (D) Esophageal squamous epithelium shows dilated intercellular spaces (upper part), and extensive vacuolization of squamous epithelial cells (lower part). (E) The subepithelial papillae reach upward to approximately three fourths the epithelial thickness. (F) Reactive atypia (vesicular nucleus and prominent nucleolus) of squamous epithelial cells is present. Magnifications: A, B, F, x400 and C, D, E, x200 (H&E stain).