Association of <i>CAV2</i> and <i>TMC6</i> variants with lung function.

<p>Each small dot in each panel represents one CF-specific FEV1 percentile value in the data set (percentiles are age- and sex-adjusted); and each individual has an average of 3.5 percentile values per year in the data set. (<b>A</b>) Mean CF-specific FEV1 percentile by age for 289 EPIC validation individuals with (red) and 283 without at least one CAV2 rs8940 derived allele (blue). FEV1 was an average of 5.5 percentile points higher among individuals with the rs8940 derived allele (p = 0.001). (<b>B</b>) Mean CF-specific FEV1 percentile by age for 59 EPIC validation individuals with (red) and 513 without at least one TMC6 rs34712518 derived allele (blue). FEV1 was an average of 8.0 percentile points lower among individuals with the rs34712518 derived allele (p = 0.01). The apparent age interaction in the diagram (growing distance between lines) was not significant here, though power is limited by the lower numbers of observations at older ages.