Quantitative analysis (average z scores) and Rest-stimulus interactions (ECN connectivity vs. high-memory-load activation) in APOE-ε4 carriers and non-carriers.

<p>(a) A bar graph of the average z scores (ECN) in both groups within the specific ROIs, where the error bar stands for the standard error. APOE-ε4 carriers had enhanced ECN connections in the bilateral anterior insula. The scatter plots of working-memory activation (3-back > 2-back) versus resting-state connectivity (ECN) within the (b) left and (c) right anterior insula in both groups. The significantly positive correlation was only found in APOE-ε4 non-carriers within the right anterior insula. ECN = executive control network.