Quantitative analysis (average z scores) and Rest-stimulus interactions (HPN connectivity vs. high-memory-load activation) in APOE-ε4 carriers and non-carriers.

<p>(a) A bar graph of the average z scores (HPN) in both groups within the specific ROIs, where the error bar stands for the standard error. APOE-ε4 carriers had decreased HPN connections in the bilateral parahippocampal regions, especially in the left parahippocampal gyrus. The scatter plots of working-memory activation (3-back > 2-back) versus resting-state connectivity (HPN) within the (b) left and (c) right parahippocampal gyri in both groups. APOE-ε4 non-carriers presented negative trend within both regions; whereas APOE-ε4 carriers showed positive trend within both regions. The significantly positive correlation was only found in APOE-ε4 carriers within the right parahippocampal gyrus. HPN = hippocampal network.