Integrated biomarker response of biochemical parameters in mice liver after a 24-day exposure.

<p>Integrated biomarker response (IBR) index was calculated by combining different biomarker signals to provide an overall description of hepatic antioxidant status of male mice (five-weeks of age) individually exposed to normal diet (Control), 1/100 wt% N117-treated food (Food), 100 mg N117/L treated by combustion lacking oxygen supplementation (CLOS), and 100 mg N117/L treated by oxygen-enriched combustion (OEC) for 24 days. The measured oxidative stress biomarkers included superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and malondialdehyde (MDA). Data are the mean ± standard deviation (SD), <i>n</i> = 6 for each data point. The asterisks indicate significance of differences (*-<i>p</i> < 0.05; **-<i>p</i> < 0.01) compared with the control using one-way ANOVA with Dunnett’s <i>t</i> test.