Serum bactericidal antibody responses of mice to mutant FHbp vaccines.

<p><b>A.</b> Control mice immunized with FHbp mutant vaccines. Each symbol represents the serum bactericidal antibody titer of an individual mouse and the horizontal lines represent the geometric mean titer (GMT) of each vaccine group. There were no statistically significant pairwise differences between the WT FHbp and either of the FHbp mutants (P≥ 0.62). <b>B.</b> Human FH transgenic mice immunized with FHbp mutant vaccines. The GMT for the R41S mutant was 13-fold higher than for the wild-type FHbp, 20-fold higher for S223R, and 19-fold higher for H248L. The P values for Mann-Whitney tests comparing each mutant group with the WT group are shown.