The proposed strategies to interfere with HBV during the chemotherapy in breast cancer patient.

<p>The phases of the patients had been divided into three stages; pre-chemotherapy, chemotherapy and post-chemotherapy. Lamivudine is given at the commencement of chemotherapy in early preemptive strategy and is given only after a significant rise of HBV DNA level in deferred preemptive strategy. If no early or deferred preemptive application of lamivudine had been given but the HBV DNA and ALT increased, the lamivudine applied to patients was used for therapeutic purpose.