HIF-1α overexpression promoted liver metastasis <i>in vivo</i>.
- Wenjing Zhang (246857)
- Xinpeng Shi (752155)
- Ying Peng (26452)
- Meiyan Wu (752156)
- Pei Zhang (232846)
- Ruyi Xie (752157)
- Yao Wu (598978)
- Qingqing Yan (752158)
- Side Liu (428794)
- Jide Wang (752159)
Publication date
June 2015
DOIAbstract
<p>Representative photographic pictures (A) and H&E staining (B) of liver of BALB/c mice five weeks after subsplenic injection of HT29 cells transduced with Ad5-HIF-1α or control viruses. White arrows indicated metastatic nodules. (C) The comparison of liver metastases between HT29-Ad5-HIF-1α mice (N = 12) and control mice (N = 8). *<i>P</i> < 0.05. (D) Confirmation of the overexpression of HIF-1α from metastatic nodules in mice injected with Ad5-HIF-1α by qPCR, compared with those injected with control viruses.</p
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