STS treatment suppresses TGF-β1 expression in the PBOO model.

<p>(A) Representative TGF-β1-immunostained rat bladder sections. (a) Sham group at 4 weeks, (b) week 4 after PBOO, (c) week 4 after PBOO+STS treatment, (d) week 8 after Sham group, (e) week 8 after PBOO, (f) week 8 after PBOO+STS treatment. TGF-β1 expression was significantly higher in the PBOO rats at weeks 4 and 8 compared with the Sham groups (<i>P</i><0.05, n = 8). STS Treatment induced decreased TGF-β1 expression (<i>P</i><0.05, n = 8). (B) Densitometric analyses performed from 8 independent experiments. Each bar represents the mean±SD for 8 rats. *<i>P</i><0.05 <i>vs</i>. sham group (n = 8); ^#<i>P</i><0.05 <i>vs</i>. PBOO group. Original magnifications, ×400.