STS treatment suppresses collagen I expression in the PBOO model.

<p>(A) Representative collagen I-immunostained rat bladder sections. (a) Sham group at 4 weeks, (b) week 4 after PBOO, (c) week 4 after PBOO+STS treatment, (d) week 8 after Sham group, (e) week 8 after PBOO, (f) week 8 after PBOO+STS treatment. Collagen I expression was significantly higher in PBOO rats at weeks 4 and 8 compared with the Sham groups (<i>P</i><0.05, n = 8). STS treatment induced decreased collagen I expression (<i>P</i><0.05, n = 8). (B) Densitometric analyses were performed from 8 independent experiments. Each bar represents the mean±SD of 8 rats. *<i>P</i><0.05 <i>vs</i>. Sham group (n = 8); ^#<i>P</i><0.05 <i>vs</i>. PBOO group. Original magnifications, ×400.