Predicted two-dimensional H2AX phosphorylation patterns with and without the 3D spreading mechanism.

<p>Example of XY projections of hit domains only (A) and of all phosphorylated domains obtained with the random expansion algorithm (B); the exposure to 1 Gy of X-rays photon radiation was simulated. The cell nucleus is represented in light grey in the background. The colour scale indicates the multiplicity of hit domains in the column of interest.