CD1d^-/- mice are less susceptible to i.n. LVS infection.

<p><b>(A)</b> Survival of B6 or Jα18^-/- mice after i.n. LVS infection. Survival of Jα18^-/- and WT mice after intranasal LVS infection (8000 cfu). Curves were compared using Log-rank (Mantel-Cox) Test. Data are from one of three similar experiments with at least 10 mice/group. <b>(B)</b> B6 or CD1d^-/- mice were infected i.n. with LVS and monitored daily for weight loss. The mean (±SD) weight of 50 animals/group in several independent experiments following intranasal infection (Accumulation of five independent experiments with 10 mice/group in each experiment) is presented. <b>(C)</b> Clinical score at various time points p.i. as determined in Materials and Methods. Data are cumulative from four similar experiments (mean+SD) with 5–10 mice/group/time point. Data were analyzed as indicated in Materials and Methods. <b>(D)</b> Survival of B6 or CD1d^-/- mice after i.n. LVS infection. Cumulative survival curves from 4 experiments with 40 mice/group. Curves were compared using Log-rank (Mantel-Cox) Test. **<i>p</i><0.01, ***<i>p</i><0.001.