The effect of blood rheological model and flow rate on the average tissue drug concentration.

<p>Increases in bulk flow rate were found to correspond with reduced area-weighted average drug concentrations (AWAC) in the tissue. Rheological models which produced larger recirculation lengths were also found to produce lower AWAC values; however, the deviation from the AWAC obtained with the Newtonian model was observed to be less than 5% for each non-Newtonian case. It was only when modelling plasma instead of blood that any considerable deviations from the Newtonian model’s AWAC were observed and even these were only observed at </p><p></p><p></p><p></p><p></p><p><mi>Q</mi><mo>′</mo></p><p><mi>h</mi><mi>i</mi><mi>g</mi><mi>h</mi></p><p></p><p></p><p></p><p></p>.<p>