Changes in endogenous substrate utilization and food intake associated with cold-induced thermogenesis in mice with variable levels of DIO.

<p>Diet-induced increase in body weight (A). Reduction in body weight during cold exposure (B). Changes in body weight (C), fat mass (D), and fat free mass (E) before and after 4 days at 4°C. Daily changes in food intake during 4 consecutive days at 4°C (F). Comparison of energy utilization from endogenous reserves and food intake in greater obese and lesser obese B6 mice (G). Correlations between daily increase in food consumed and internal body reserves mobilized per day during 4 days in the cold (H). Data are expressed as mean ± SEM. *, significant differences (<i>t</i> test, *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.005; ****, <i>P</i> < 0.001). FI, food intake; FM, fat mass; FFM, fat free mass.