Internalization of GPR4 in response to acidification and its inhibition by compound 1.
- Ayaka Tobo (754036)
- Masayuki Tobo (482814)
- Takashi Nakakura (482811)
- Masashi Ebara (754037)
- Hideaki Tomura (482813)
- Chihiro Mogi (482809)
- Dong-Soon Im (754038)
- Naoya Murata (754039)
- Atsushi Kuwabara (754040)
- Saki Ito (754041)
- Hayato Fukuda (754042)
- Mitsuhiro Arisawa (754043)
- Satoshi Shuto (102368)
- Michio Nakaya (431495)
- Hitoshi Kurose (288680)
- Koichi Sato (207269)
- Fumikazu Okajima (482819)
Publication date
June 2015
DOIAbstract
<p>Permanent cell line expressing GFP-conjugated GPR4 or V<sub>1a</sub> vasopressin receptor was incubated for 1 h with or without 1 μM [Arg<sup>8</sup>]-vasopressin (AVP) or 1 μM compound 1 (C1) under the indicated pH to monitor of receptor internalization. After fixation, nucleus was stained with DAPI (blue) and localization of GFP-receptor (green) was monitored. Scale bar: 20 μm. The results are representative of three to four separate experiments. The higher magnification image of the small square is shown in the large square.</p
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