Influence of a humanized anti-CSP mAb 2A10 on <i>P</i>. <i>falciparum</i> traversal and invasion.

<p>Sporozoites were added at a 4.5:1 sporozoite-to-hepatocyte ratio. Cells were infected in the presence of h2A10 or pre-2A10-AAV serum at varying dilutions. (A) Percentage of traversed cells measured by dextran uptake 6 hours postinfection. Representative flow plots for (B) HC-04 48 hours postinfection and (C) donor 4051 96 hours postinfection. Graphs indicated the number, percentage and geometric MFI of GFP-positive events in duplicate. Mean +/- SD shown on all graphs.