<p>Lung function was determined in WT and βENaC-Tg mice after exposure to air or CS for 4 weeks. <b>(A)</b> Resistance (R) of the entire compartment (airways, tissue and chest wall). <b>(B)</b> Tissue damping (G), related to tissue resistance. <b>(C)</b> Tissue elasticity (H). <b>(D)</b> Static compliance (C<sub>stat</sub>). <b>(E)</b> Dynamic compliance (C<sub>dyn</sub>). <b>(F)</b> Total lung capacity (TLC). *p<0.05, **p<0.01, ***p<0.001.</p
Much is known about the chronic effects of cigarette smoke (CS) on lung function and inflammation an...
Most studies using mice to model human lung diseases are carried out in adults, although there is em...
<p>IL-1β, IL-18, IL-18R or caspase 1/11 <sup>-/-</sup> mice were exposed to CS or room air (control)...
<p>WT and RAGE<sup>-/-</sup> mice were exposed to CS or room-air for six months. Total lung capacity...
<p><b>(A)</b> Mean linear intercept (Lm) upon 4 weeks of air or CS exposure. n = 7-8/group. Represen...
<p>Respiratory mechanics of RAGE-/- mice and wild type mice (n = 5–6 mice per strain per treatment g...
<p>(A) Peak expiratory flow (PEF); (B) Peak inspiratory flow (PIF); (C) Minute ventilation (MV), wer...
<p>Increased total number of cells after CS-exposure in BAL fluid of susceptible mouse strain was fo...
<p>(A) and (D) are lung micrographs of a p66Shc−/− mouse at 7 months after CS exposure. (B) and (D) ...
Respiratory pathologies alter the structure of the lung and impact its mechanics. Mice are widely us...
<p><b>(A)</b> Total inflammatory cell count in BAL upon 4 weeks of air or CS exposure. Quantificatio...
<p>Scatter plot showing the correlation (r = 0.54) between Factor 2 (lung function) and Factor 1 (in...
<p>Male BALB/c mice were either exposed to 6 cigarettes/day, 6 days/week (▪) or sham handled (□) for...
<p>(A) Longitudinal changes in body weight of air- exposed (open triangle: <i>n</i> = 5) and CS-expo...
<p>Mice were exposed to CS for 3 months and treated with icariin (25, 50 and 100 mg/kg) or dexametha...
Much is known about the chronic effects of cigarette smoke (CS) on lung function and inflammation an...
Most studies using mice to model human lung diseases are carried out in adults, although there is em...
<p>IL-1β, IL-18, IL-18R or caspase 1/11 <sup>-/-</sup> mice were exposed to CS or room air (control)...
<p>WT and RAGE<sup>-/-</sup> mice were exposed to CS or room-air for six months. Total lung capacity...
<p><b>(A)</b> Mean linear intercept (Lm) upon 4 weeks of air or CS exposure. n = 7-8/group. Represen...
<p>Respiratory mechanics of RAGE-/- mice and wild type mice (n = 5–6 mice per strain per treatment g...
<p>(A) Peak expiratory flow (PEF); (B) Peak inspiratory flow (PIF); (C) Minute ventilation (MV), wer...
<p>Increased total number of cells after CS-exposure in BAL fluid of susceptible mouse strain was fo...
<p>(A) and (D) are lung micrographs of a p66Shc−/− mouse at 7 months after CS exposure. (B) and (D) ...
Respiratory pathologies alter the structure of the lung and impact its mechanics. Mice are widely us...
<p><b>(A)</b> Total inflammatory cell count in BAL upon 4 weeks of air or CS exposure. Quantificatio...
<p>Scatter plot showing the correlation (r = 0.54) between Factor 2 (lung function) and Factor 1 (in...
<p>Male BALB/c mice were either exposed to 6 cigarettes/day, 6 days/week (▪) or sham handled (□) for...
<p>(A) Longitudinal changes in body weight of air- exposed (open triangle: <i>n</i> = 5) and CS-expo...
<p>Mice were exposed to CS for 3 months and treated with icariin (25, 50 and 100 mg/kg) or dexametha...
Much is known about the chronic effects of cigarette smoke (CS) on lung function and inflammation an...
Most studies using mice to model human lung diseases are carried out in adults, although there is em...
<p>IL-1β, IL-18, IL-18R or caspase 1/11 <sup>-/-</sup> mice were exposed to CS or room air (control)...