The effects of PI3K/AKT inhibition on hyperoxic lung injury in <i>Nrf2</i>^<i>+/+</i> and <i>Nrf2</i>^{<i>–/–</i>}mice post-injury.

<p><i>Nrf2</i>^{<b><i>+/+</i></b>} and <i>Nrf2</i>^{<b><i>–/–</i></b>}mice were treated with vehicle or LY during hyperoxia as well as post-injury (recovery) from hyperoxia for 72 h at every 24 h intervals. Lung injury and inflammation was assessed as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129676#pone.0129676.g001" target="_blank">Fig 1</a>. Lung alveolar permeability of <i>Nrf2</i>^{<b><i>+/+</i></b>} (A) and <i>Nrf2</i>^{<b><i>–/–</i></b>}(B) mice post hyperoxic injury. The horizontal and vertical lines were plotted as median ± interquartile range for each group (n = 4–5). One-way ANOVA with Bonferroni corrections was performed for multiple group comparisons. *<i>P</i> = 0.05, hyperoxia vs room air; ^{<b><i>†</i></b>}<i>P</i> = 0.05, vehicle vs LY treated group.