Injection AAV-HBV induces chronic liver injury but not acute inflammation.

<p>Serum and liver samples were collected from HBV(+) and HBV(-) mice at the indicated time points. (a) ALT and AST levels. (b) Liver samples stained with hematoxylin and eosin to detect inflammatory responses and with Masson’s stain and Sirus red stain to detect collagen deposition. Black arrows, inflammatory cell infiltration; blue arrows, fat vacuoles; yellow and white arrows, collagen deposition. HBV(-) mice, PBS injected mice.