<i>Cxadr</i> is highly expressed during kidney development.

<p><b>(A-D)</b> In-Situ-Hybridization showed intense expression of <i>Cxadr</i> in E15.5 embryos, especially in the nervous system, gut, lung and kidney. <b>(E&F)</b> After birth at P1 and P14 <i>Cxadr</i> could be detected in glomerular cells as well as in the nephron (<i>thick ascending limb of Henle</i>). <b>(G)</b> Western blot confirmed CXADR expression in heart, kidney, lung, brain and more specifically in isolated murine podocytes. <b>(H-K)</b> Developmental assessment of <i>Cxadr</i> expression during kidney development started in the S-shaped body phase where podocytes and parietal epithelial cells formed a continuous stretch of cells. <b>(L&M)</b> In both, podocytes (arrows) and parietal epithelial cells (asterisk) CXADR could be robustly detected in the early capillary loop stage, while mature glomeruli only possessed reduced amounts of CXADR in podocytes.