Mendelian randomization estimates of the association of systolic blood pressure with AD in individual ADGC studies and overall in ADGC, GERAD1, and IGAP.

Søren D. Østergaard (755482)
Shubhabrata Mukherjee (481272)
Stephen J. Sharp (198654)
Petroula Proitsi (228861)
Luca A. Lotta (397633)
Felix Day (755483)
John R. B. Perry (150215)
Kevin L. Boehme (755484)
Stefan Walter (487437)
John S. Kauwe (755485)
Laura E. Gibbons (755486)
Eric B. Larson (393562)
John F. Powell (58019)
Claudia Langenberg (160616)
Paul K. Crane (393556)
Nicholas J. Wareham (110277)
Robert A. Scott (160581)

Publication date

June 2015

DOI

10.1371/journal.pmed.1001841.g001

Abstract

<p>This figure shows MR estimates for the association of SBP-associated variants with AD in each of the participant studies in ADGC [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001841#pmed.1001841.ref024" target="_blank">24</a>] and in GERAD1 [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001841#pmed.1001841.ref025" target="_blank">25</a>] using individual SNP-level data compared to that observed in IGAP [<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001841#pmed.1001841.ref012" target="_blank">12</a>] using summary-level data. See <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001841#pmed.1001841.s015" target="_blank">S1 ...