<p>(<b>A</b>) Sixty percent of mice (n = 9/15) challenged (right leg) with Id2 knock down Neuro2a (Id2kdN2a) cells rejected tumor and survived tumor-free, whereas all mice challenged with either wild type Neuro2a (wtN2a, n = 20) or scrambled shRNA lentivirus transfected Neuro2a (sc-shRNA-N2a, n = 5)) cells died from tumor burden. (<b>B</b>) Tumor free survivors from (A) were re-challenged with wtN2a cells into their left leg 6 weeks after they cleared the tumor and 8 out of 9 mice were protected from tumor growth. (<b>C</b>) SCID and nude mice grew tumors aggressively following inoculation with Id2kdN2a cells. (<b>D</b>) Following inoculation of wtN2a cells in the right leg, Id2kdN2a (n = 10) and wtN2a (n = 5) cells were vaccinated into the...
<p>Groups of Balb/c mice (n = 10) 4 weeks old were inoculated with two doses of the DNA vaccine pcTP...
<p>A/J mice were inoculated with 1 × 10<sup>6</sup> wild-type (WT) N2a, and once tumors were establi...
<p>(A) HLA-A2<sup>+</sup> transgenic mice were vaccinated i.m a total of 4 times, separated by 2 wee...
Tumor vaccines have held much promise, but to date have demonstrated little clinical suc-cess. This ...
Tumor vaccines have held much promise, but to date have demonstrated little clinical success. This l...
Tumor vaccines have held much promise, but to date have demonstrated little clinical suc-cess. This ...
<p>(<b>A</b>, <b>B</b>) Representative mouse from untreated and combination therapy group showing gr...
<p>(<b>A</b>) Western blot analysis reveals complete knockdown of Id2 on Neuro2a AD cells transduced...
<p>(<b>A</b>) Schematic diagram of the therapeutic vaccine strategy. Two established tumor models, n...
<p>Neuro-2a murine neuroblastoma tumor cells (5 × 10<sup>5</sup> cells) were injected into the right...
<p>(A) Expression of Id1 in KMM-sh<i>Ctrl</i> and KMM-sh<i>Id1</i> cells were checked by immunostain...
The activation NKG2D receptor has been shown to play an important role in the control of experimenta...
<p>(A, B) The preventive effect of B16-mBD2 vaccination on the development of tumors. Groups of C57B...
<p>The graphs represents from the left; “UC” –unchallenged mice, i.e. control Id-specific TCR-transg...
We designed multimodal tumor vaccine that consists of irradiated tumor cells infected with the oncol...
<p>Groups of Balb/c mice (n = 10) 4 weeks old were inoculated with two doses of the DNA vaccine pcTP...
<p>A/J mice were inoculated with 1 × 10<sup>6</sup> wild-type (WT) N2a, and once tumors were establi...
<p>(A) HLA-A2<sup>+</sup> transgenic mice were vaccinated i.m a total of 4 times, separated by 2 wee...
Tumor vaccines have held much promise, but to date have demonstrated little clinical suc-cess. This ...
Tumor vaccines have held much promise, but to date have demonstrated little clinical success. This l...
Tumor vaccines have held much promise, but to date have demonstrated little clinical suc-cess. This ...
<p>(<b>A</b>, <b>B</b>) Representative mouse from untreated and combination therapy group showing gr...
<p>(<b>A</b>) Western blot analysis reveals complete knockdown of Id2 on Neuro2a AD cells transduced...
<p>(<b>A</b>) Schematic diagram of the therapeutic vaccine strategy. Two established tumor models, n...
<p>Neuro-2a murine neuroblastoma tumor cells (5 × 10<sup>5</sup> cells) were injected into the right...
<p>(A) Expression of Id1 in KMM-sh<i>Ctrl</i> and KMM-sh<i>Id1</i> cells were checked by immunostain...
The activation NKG2D receptor has been shown to play an important role in the control of experimenta...
<p>(A, B) The preventive effect of B16-mBD2 vaccination on the development of tumors. Groups of C57B...
<p>The graphs represents from the left; “UC” –unchallenged mice, i.e. control Id-specific TCR-transg...
We designed multimodal tumor vaccine that consists of irradiated tumor cells infected with the oncol...
<p>Groups of Balb/c mice (n = 10) 4 weeks old were inoculated with two doses of the DNA vaccine pcTP...
<p>A/J mice were inoculated with 1 × 10<sup>6</sup> wild-type (WT) N2a, and once tumors were establi...
<p>(A) HLA-A2<sup>+</sup> transgenic mice were vaccinated i.m a total of 4 times, separated by 2 wee...