Splicing of XBP1 mRNA is dependent on the ER stress responsive kinase IRE1α.

<p>Splicing of <i>XBP1</i> mRNA in 16HBE cells after treatment with CM-PAO1 in the presence of 30 μM 4μ8C, a selective inhibitor of the ER stress responsive kinase IRE1α (n = 3; mean ± SEM). All values are normalised to the housekeeping genes <i>RPL13A</i> and <i>ATP5B</i>. * p<0.05, ** p<0.01, *** p<0.001 versus untreated (-) with a two-way repeated-measurements ANOVA (Bonferroni <i>post-hoc</i>).