Transplanted iPSCs differentiate into GFAP⁺ neural cells in the perihematomal regions and enhance the functional recovery of ICH rats.

<p>(A) Passaged iPSCs displayed typical colonies (left) and positive AP (right; bar=200 μm). (B) Immunofluorescence for GFAP showed the CM-Dil labeled iPSCs within the perihematomal regions differentiated into neural cells at day 28 post ICH. The # sign indicates hematoma areas. Bar=20 μm. (C) Changes in scores of MLPT in rats of 3 groups (Sham; PBS; PBS+iPSCs) over time after treatment. Shown are the mean values with SEM from 8 rats for each group. *<i>P</i><0.05 for differences between PBS and PBS+iPSCs groups at days 14 to 42 post ICH.