<p>A group of transferase enzymes add either a sugar unit (ex: along A-series pathway) or a sialic acid residue (ex: A to B series pathways) to synthesize different ganglioside species. A different set of enzymes breaks down these components to increase levels of simpler species thus a homeostatic level of each ganglioside species is maintained in a healthy organism.</p
PhDBiochemistryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.l...
AbstractSynthesis of ganglioside GDD1b from ganglioside GD2 was demonstrated using Golgi membranes i...
Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the most abun...
<p>The main gangliosides found in brain are a-series and b-series gangliosides (encircled). Ganglios...
<p>Gangliosides are classified in 4 series according to the number of sialic acid residues linked to...
<p>The glycan parts of important members are shown for each series. The downstream biosynthetic step...
Since the structure of GM1 was elucidated 55years ago, researchers have been attracted by the sialyl...
AbstractFrom a functional standpoint, glycosyltransferases (GTases) comprise one the most diverse gr...
<p>Cer, ceramide; LacCer, lactosylceramide. GM1, GD1a, GD1b and GT1b comprise up to 97% of all gangl...
Gangliosides are a large group of complex lipids found predominantly on the outer layer of the plasm...
AbstractCompetition experiments using GM1b, GD1a and GT1b as substrates, and as mutual inhibitors fo...
AbstractA new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuro...
In this review, the focus is on the role of salvage pathways in glycosphingolipid, particularly, gan...
Glycogen and starch are complex branched polymers of glucose that serve as units of glucose storage ...
AbstractClassically, α-1,4-glucan synthases have been divided into two families, animal/fungal glyco...
PhDBiochemistryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.l...
AbstractSynthesis of ganglioside GDD1b from ganglioside GD2 was demonstrated using Golgi membranes i...
Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the most abun...
<p>The main gangliosides found in brain are a-series and b-series gangliosides (encircled). Ganglios...
<p>Gangliosides are classified in 4 series according to the number of sialic acid residues linked to...
<p>The glycan parts of important members are shown for each series. The downstream biosynthetic step...
Since the structure of GM1 was elucidated 55years ago, researchers have been attracted by the sialyl...
AbstractFrom a functional standpoint, glycosyltransferases (GTases) comprise one the most diverse gr...
<p>Cer, ceramide; LacCer, lactosylceramide. GM1, GD1a, GD1b and GT1b comprise up to 97% of all gangl...
Gangliosides are a large group of complex lipids found predominantly on the outer layer of the plasm...
AbstractCompetition experiments using GM1b, GD1a and GT1b as substrates, and as mutual inhibitors fo...
AbstractA new class of gangliosides, GT1aα and GQ1bα, were initially identified as cholinergic neuro...
In this review, the focus is on the role of salvage pathways in glycosphingolipid, particularly, gan...
Glycogen and starch are complex branched polymers of glucose that serve as units of glucose storage ...
AbstractClassically, α-1,4-glucan synthases have been divided into two families, animal/fungal glyco...
PhDBiochemistryUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.l...
AbstractSynthesis of ganglioside GDD1b from ganglioside GD2 was demonstrated using Golgi membranes i...
Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the most abun...