Quantification of intensity and shape features of ChIP-seq signals.

<p>A) Graphical representation of four parameters <i>Max</i>, <i>Kurtosis</i>, <i>Skewness</i> and <i>Bimodality</i>. The dashed curves indicate standard normal distribution, and the light blue area under curve indicates a probability distribution with the corresponding parameter changed. The boxplots of the four parameters and significances of the difference between enhancers and promoters for B) H3K4me1, C) H3K4me2 and D) H3K4me3 in CD4⁺ T cells. Significance (<i>P</i>-value) of the difference between two means was calculated by Wilcoxon rank-sum difference test.