Effect of different stimulus intensities on the amplitudes of the a- and b-waves of the scotopic (A) and photopic (B) ERGs of wild type (WT) and Pika-/- mice.

<p>(A) Scotopic flash ERGs elicited by 11 different stimulus intensities (from -5.0 to 1.0 log cd-s/m²), and photopic flash ERGS elicited by 9 different stimulus intensities (from -1.4 to 1.0 log cd-s/m²) recorded in a representative WT mouse and a representative Pika-/- mouse. (B) The intensity–response curves of the mean scotopic and photopic b-wave amplitudes of five WT mice and five Pika-/- mice are shown in the upper left and lower left panels respectively. The amplitudes of the scotopic b-wave of WT mice were not significantly different from that of Pika-/- mice (P >0.05: repeated measures ANOVA). However, the amplitudes of the photopic b-wave of Wt mice were significantly different from Pika-/- mice (P <0.05: repeated measures ANOVA). In addition, the intensity–response curves of the mean scotopic and photopic b-wave implicit times are shown in the upper right and lower right panel respectively. The implicit times of the scotopic and photopic b-waves of WT mice were significantly different from Pika-/- mice (P <0.05: repeated measures ANOVA).The means ± SDs are plotted. ● = WT mice and ○ = Pika-/- mice.