Comparison of experimentally determined and docked conformations of SAH (A) and the SAH-based inhibitor 36A (B) in the SAM-binding pocket of the DENV3 MTase.

<p>The MTase was in cartoon representation in grey color with representative contact residues in stick representation. Ligands (SAH or 36A) were in stick representation. Colors for atoms unless specified: oxygen, red; nitrogen, blue; carbon for MTase residues, grey; carbon for ligands (crystallography-determined), magenta; carbon for ligands (docked), cyan.