Protective Efficacy of TMV-Conjugate Vaccine.

<p><b>(A)</b> C57BL/6 mice (N = 8 per group) immunized with TMV-monoconjugate vaccine; <b>(C)</b> with TMV-multiconjugate vaccine (schedule I) or <b>(E)</b> with TMV-multiconjugate vaccine (Schedule II) were challenged i.n. with 10xLD₁₀₀ of <i>F</i>. <i>tularensis</i> LVS on day 28 post-immunization. Mice vaccinated with TMV alone were used as controls. Challenged mice were observed for morbidity and mortality for a period of 21 days post-challenge. The survival results are expressed as Kaplan-Meier survival curves and statistical analysis was performed using Log-rank test. <b>(B, D and F)</b> Body weight of the challenged mice at the indicate time points. The data are represented as Mean ± S.D.