Genetic elimination of FXIII prolongs colitis symptoms.
- Christina Andersson (758618)
- Peter H. Kvist (758619)
- Kathryn McElhinney (758620)
- Richard Baylis (758621)
- Luise K. Gram (758622)
- Hermann Pelzer (758623)
- Brian Lauritzen (758601)
- Thomas L. Holm (758624)
- Simon Hogan (758625)
- David Wu (257995)
- Brian Turpin (758626)
- Whitney Miller (758627)
- Joseph S. Palumbo (758628)
Publication date
June 2015
DOIAbstract
<p>FXIII<sup>−/−</sup> mice (◯) challenged with DSS develop significantly worse clinical signs of disease relative to WT mice (●) based on a multiparameter Disease Activity Index score (A) and weight loss (B). Note that body mass continued to decline in FXIII<sup>−/−</sup> mice even after DSS was withdrawn, whereas body mass stabilized and improved in WT animals during this period. <i>P</i> values were generated with a 2 way ANOVA, n = 10 mice per cohort.</p
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