Immunogenicity of inter-protomer disulfide stabilized RSV F variants.

<p>Neutralization titers of sera from mice immunized with 10 μg of RSV F variants in the presence of 50 μg of poly I:C adjuvant are shown (10 mice/group). Titers from individual mice are shown as individual colored dots, and the geometric mean of each group is indicated by a red horizontal line. Protective threshold [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128779#pone.0128779.ref018" target="_blank">18</a>] at a neutralization titer of 100 is indicated by a dotted line, and statistical significance as assessed by a Mann-Whitney Unpaired non-parametric two-tailed test followed by false discovery rate correction are shown for post-fusion, ring A, ring ABCD, and DS-Cav1 RSV F immunized groups.