miR-137 active cell apoptosis and negatively regulate cell invasion by targeting AKT2.

<p><b>A.</b> AKT2 protein level was assessed in GC cells treated by overexpression of miR-137 and/ or AKT2. <b>B.</b> AKT2 restoration leads to a suppression of apoptosis in GC cells while miR-137 promotes apoptosis. <b>C.</b> AKT2 restoration actives the apoptosis and invasion of GC cells while miR-137 showed opposite effects. Representative images are shown. The normalized ratio of invasive cells is shown in the bottom panels. In Fig 5, “miR-137” represents the cells transfected by miR-137 and pcDNA 3.1 empty vector. “AKT2_oe” represents the cells transfected by AKT2 overexpression vector. “miR-137 +AKT2_oe” represents the cells co-transfected by miR-137 and AKT2 overexpression vector. “Scr” represents the cells transfected with mimic negative control and pcDNA 3.1 empty vector.