Blunted IR signaling in cells bearing mutant BBS1 protein.

<p><b>A</b>) MEF cells obtained from <i>Bbs1</i>^{<i>M390R/M390R</i>} mice have reduced Akt activation (pAKT^<i>S473</i>) in response to insulin when compared to cells obtained from wild-type littermate controls. (<b>B</b>) Insulin-induced Akt activation was also blunted in fibroblasts derived from <i>BBS1</i>^{<i>M390R/M390R</i>} patients relative to control cells. *P<0.05 versus WT or vehicle, ^<i>#</i>P<0.05 versus WT-Insulin; all data are expressed as means ± SEM.