Femoral BV/TV, Tb.Th, Tb.N, and Tb.C during long-term imatinib exposure.

<p>Three dimensional trabecular microarchitecture of the right femora was assessed by μCT. Trabecular region of interest was defined manually located within the secondary spongiosa in prepubertal femora 196 slices, pubertal femora 226 slices, and in postpubertal femora 256 slices. For trabecular bone regions, bone volume/ total volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular connectivity (Tb.C) were calculated. Data represents mean ± 95% CI. Prepubertal = age of rats: 6 weeks, duration of exposure: 2 weeks (n = 4 each group); Pubertal = age of rats: 8 weeks, duration of exposure: 4 weeks (n = 3 each group); Postpubertal = age of rats: 14 weeks, duration of exposure: 10 weeks (n = 3 each group). Statistical analysis at defined time points: * p<0.05 versus age-related controls; ** p<0.01 versus age-related controls; *** p<0.001 versus age-related controls.