Areca nut and TGF-β induced transcriptome profile in fibroblast (hGF) cells.

<p>a] Venn diagram representing differentially regulated genes by areca nut and/or TGF-β in hGF cells. b] Hierarchal cluster of the 413 genes commonly regulated in hGF by areca nut water extract (5H) and areca nut with TGF-β (5H+T). c] Hierarchal cluster of 60 genes oppositely regulated in hGF by areca nut (5H) and TGF-β (T). d] Hierarchal cluster of 3153 genes commonly regulated in hGF by areca nut (5H) and areca nut with TGF-β (5H+T) treatment. e] Hierarchal cluster of genes (494) whose regulation by TGF-β (T) is not influenced by the addition of areca nut (5H). In all hierarchal clusters; red, green and black colours represent up, down and un-regulated genes respectively. The rows represent genes and columns represent various treatments of areca nut on hGF cells (5H; 5 μg/ml) and/or TGF-β (T; 5 ng/ml).