Functional interaction map generated by using Ingenuity Pathway Analysis (IPA).

<p>Tissue-specific prediction of SPARC-interacting protein network in the liver (A) and pancreas (B). Each node represents a protein and its biological relationship with other proteins is represented by a line or edge (either solid or dotted). Solid lines indicate direct relationships between proteins; dotted lines indicate indirect functional relationships. Nodes have different shapes to represent different functional classes as indicated in the legend within the figure. Nodes with bold outline represent SPARC (red color) and its interacting partner proteins (blue color) in the liver (BHMT, CA3, CPS1, and RARhoGAP/ARHGAP20) and pancreas (AMY2/PA and APC2). Proteins or nodes with no color were undetected in the study but have been incorporated by IPA to produce a highly connected network. A full list of cellular functions given by IPA for the molecular networks is provided along with statistical evidence in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131189#pone.0131189.s002" target="_blank">S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131189#pone.0131189.s003" target="_blank">S2</a> Tables. Cellular functions involving only SPARC and its interacting proteins in the liver and pancreas were extracted from the main lists and given in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131189#pone.0131189.s004" target="_blank">S3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131189#pone.0131189.s005" target="_blank">S4</a> Tables, respectively.