A possible model for the HMGA2 homodimerization.

<p>Blue lines represent the protein backbone. Electrostatic interactions between the positively charged “AT hooks” (red rectangle with two red circles) and the negatively charged C-terminus (yellow oval) coordinate the dimer formation. <b>(A)</b> represents HMGA2 monomers. <b>(B)</b> and <b>(C)</b> represent different interchangeable conformations of HMGA2 homodimers. <b>(C)</b> is more consistent with our EDC cross-linking and sedimentation velocity results. The HMGA2 homodimers may be an ensemble of different conformers.