Gene dosage effects of HGS expression on motor and sensory function in 3- to 4-week-old mice.

<p>(A) Reduced HGS expression results in clawed paws in <i>Hgs</i>^<i>tn/tn</i> mice. Behavioral assays of (B) open field, (C) rotarod, (D) elevated beam, (E) von Frey and (F) forelimb grip strength for <i>Hgs</i>^<i>+/+</i> (black), <i>Hgs</i>^<i>tn/+</i>, <i>Hgs</i>^<i>tn/tn</i> and <i>Hgs</i>^KO/+ mice. n = 6 mice per genotype for all assays except rotarod, where n = 4. Symbols represent unpaired t-tests corrected for multiple comparisons using the Holm-Sidak method. Data are shown as mean ± SE and n>6 animals per genotype for all assays except rotarod, where n = 4. A two-way anova demonstrated a significant effect of genotype on rotarod and elevated beam performance. Data are shown as mean ± SE. *p<0.05, **p<0.01 and ***p<0.001.