Percentage of top <i>c</i>% ranked proteins, identified by LSED-XC methods and XC methods, to be essential proteins of <i>Drosophila melanogaster</i>.

<p>Eight centrality methods (DC, BC, CC, SC, EC, IC, NC, and ION) were adopted to calculate centrality scores from the global PIN, respectively. LSED was combined with these centrality methods to calculate Localization-specific Centrality Scores from PSLINs separately. In (a)-(f), all the centrality methods are denoted as XC in the legend, and LSED with different XC methods are denoted as LSED-XC in the legend. The proteins are ranked in the descending order based on their Localization-specific Centrality Scores (<i>LCSs</i>) and centrality scores computed by LSED-XC methods and XC methods, respectively. Then, top 1%, 5%, 10%, 15%, 20% and 25% of the ranked proteins are selected as candidates for essential proteins. According to the list of known essential proteins, the percentages of true essential proteins were calculated. The figure shows the percentage of true essential proteins identified by each method in each top percentage of ranked proteins. The digits in brackets stand for the number of proteins ranked in each top percentage. For example, the total number of ranked proteins of <i>Drosophila melanogaster</i> is 8,020, thus the number of proteins ranked in top 1% is about 80 (= 8,020 *1%).