Effects of clarithromycin on TGFβ-1, CTGF, and collagen type I gene expressions and on tissue collagen concentration.

<p>(A) TGFβ-1 expression in lungs of control (CTL), radiation only (RT), radiation + clarithromycin (RT+CLA), and clarithromycin only (CLA) animal groups. (B) CTGF and collagen type I gene expressions in lungs of respective groups. Densitometry values were normalized to β-actin and data are presented as mean ± SEM (n = 2–6 mice per group). (C) Collagen concentration in lung tissue by group (n = 2–9 mice per group, Sircol collagen assay). *<i>p</i><0.05 vs CTL mice; †<i>p</i><0.05 vs RT mice.