miR-155 deficiency delays lymphoproliferative disease in LAT-KI mice.

<p>(A) Photographs of spleens and axillary, brachial and inguinal lymph nodes from WT (C57BL/6), miR155^<b>-/-</b>, LAT-KI and DM (LAT-KI/miR155^<b>-/-</b>) mice. Ages of the mice were 9 wks (WT) and 8 wks (other three genotypes). Photographs are representative of 9 experiments. (B) Spleen weights of mice of the indicated genotypes over time. Each symbol represents an individual mouse. (C) CD4 and CD8 surface marker expression as measured by flow cytometry. Ages of the mice were 11 wks (WT), 9 wks (miR155^<b>-/-</b>), 10 wk (LAT-KI), 10 wks (DM) and 19 wks (DM-old). The results are representative of 9 experiments. (D) Number of CD4^<b>+</b> T cells from axillary, brachial and inguinal lymph nodes of 8–10 wk old mice of the indicated genotypes. Each symbol represents an individual mouse.