Inhibition of PGT by oral T26A raises urinary and plasma PGE₂ concentrations in awake, ambulatory mice.

<p>Mice were kept in metabolic cages and fed with regular water and food for 5 days. Vehicle (2% DMSO + 2% cremophor) or 2 mM T26A was added to the drinking water on day 6. Urines were collected every 24 hours and averaged as in the text. On day 25, blood was drawn by cardiac puncture. <b>A,</b> PGE_<b>2</b> levels in urine of mice on oral vehicle or T26A. <b>B,</b> PGE_<b>2</b> levels in plasma of mice at the termination of the study. Values are mean ± SEM, n = 6 mice each, *p < 0.05.