Angiographic progression of MMD in an adult patient with intracranial stenosis.

<p>A 42-year-old female presented with transient numbness and clumsiness of her left hand. She had mild stenosis on bilateral and proximal middle cerebral arteries. There was no stenosis of the distal internal carotid artery and basal collaterals, called Moyamoya vessels, on conventional angiography (upper lane). Angiographic findings taken one year later show the progression of stenosis and Moyamoya vessels bilaterally (lower lane). Genetic study revealed <i>RNF213</i> mutation associated with MMD (p.Arg4810Lys).