Similarity between subtypes distribution in the METABRIC discovery and validation sets, and in the ROCK set.

<p>The image shows the similarity between the subtypes distribution for METABRIC discovery (MD) and validation (MD) sets, and ROCK test set (RS). The labels were assigned in the original data sets using the PAM50 method, and relabelled in this study with an ensemble learning using PAM50 and CM1 lists. The similarity is measured using the square root of the Jensen-Shannon divergence. Darker shades represent more similar distributions, while lighter shades refer to divergent patterns. The diagonal shows the darkest color as each data set is the closest to itself. According to this image, labels assigned using an ensemble learning with CM1 and PAM50 lists are highly similar, and both exhibit lower levels of agreement with the original labels assigned using a single classifier (PAM), or PAM50 method.