Dietary 2-DG reduces blood glucose, serum insulin and PI3K/AKT signalling.

<p>2-DG administration reduces (A) blood glucose, (B) serum insulin in EAC tumor bearing mice (day 28) as observed in the non-tumor bearing mice shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132089#pone.0132089.g002" target="_blank">Fig 2E and 2F</a>), and down-regulated (C) PI3K/Akt signalling in tumors. Western blot results revealed reduced expression of PI3K, phosphorylated-Akt and HIF-1α. No changes were observed in the expression levels of Glut-1 and T-Akt. β-Actin was used as loading control.