<p>(A) Myeloid cell populations in lung 30 days post-infection were characterized by flow cytometry. (B) Flow cytometry analysis of total CD4+ T cells and IFN-γ, IL-17 and TNF production by CD4+ T cells restimulated with PMA and ionomycin in the presence of brefeldin A. Graphs show the mean ± SEM value of one representative experiment of at least two independent ones (n = 5). The gating strategies and representative plots are in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0131904#pone.0131904.s001" target="_blank">S1 Fig</a>. Significance was determined by the Student’s <i>t</i>-test.</p
Because tuberculosis (TB) is primarily a pulmonary disease, we examined the cytokine responses of CD...
Background: Tuberculosis is one of the world’s leading killers, stealing 1.4 million lives and causi...
Mice infected with fluorescent protein-expressing M. tuberculosis were injected with EdU and its inc...
<p>B6 mice were infected with ∼100 CFU <i>M.tuberculosis</i> via the aerosol route and treated with ...
<p>Infiltrating cells in the lungs of IL-36R deficient (right panels) and wild-type mice (left panel...
<div><p>Sirtuins (Sirts) regulate several cellular mechanisms through deacetylation of several trans...
<p>B6 mice were infected with ∼100 CFU <i>M.tuberculosis</i> via the aerosol route and at specific t...
<p>WT and IDO-1<sup>−/−</sup> mice were infected with <i>M. tuberculosis</i> (100 CFU). Single cell ...
<p>Lung tissues and spleens were homogenised and passed through nylon wool columns. The isolated T l...
<p>(<b>a</b>) <i>Ex vivo</i> assessment of the cell phenotypes within the pleural fluid. Shown are r...
Although monitoring tuberculosis (TB) infection during long-term treatment with TNF antagonists is o...
Differential T cell trafficking through the blood compartment towards infected foci may be occurring...
<p>C57BL/6 mice were infected with <i>M. tuberculosis</i> H37Rv-GFP via the respiratory route and th...
<p>RNA was extracted from the lung tissue after 30 days of infection and the expression of <i>Ifn</i...
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung,...
Because tuberculosis (TB) is primarily a pulmonary disease, we examined the cytokine responses of CD...
Background: Tuberculosis is one of the world’s leading killers, stealing 1.4 million lives and causi...
Mice infected with fluorescent protein-expressing M. tuberculosis were injected with EdU and its inc...
<p>B6 mice were infected with ∼100 CFU <i>M.tuberculosis</i> via the aerosol route and treated with ...
<p>Infiltrating cells in the lungs of IL-36R deficient (right panels) and wild-type mice (left panel...
<div><p>Sirtuins (Sirts) regulate several cellular mechanisms through deacetylation of several trans...
<p>B6 mice were infected with ∼100 CFU <i>M.tuberculosis</i> via the aerosol route and at specific t...
<p>WT and IDO-1<sup>−/−</sup> mice were infected with <i>M. tuberculosis</i> (100 CFU). Single cell ...
<p>Lung tissues and spleens were homogenised and passed through nylon wool columns. The isolated T l...
<p>(<b>a</b>) <i>Ex vivo</i> assessment of the cell phenotypes within the pleural fluid. Shown are r...
Although monitoring tuberculosis (TB) infection during long-term treatment with TNF antagonists is o...
Differential T cell trafficking through the blood compartment towards infected foci may be occurring...
<p>C57BL/6 mice were infected with <i>M. tuberculosis</i> H37Rv-GFP via the respiratory route and th...
<p>RNA was extracted from the lung tissue after 30 days of infection and the expression of <i>Ifn</i...
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung,...
Because tuberculosis (TB) is primarily a pulmonary disease, we examined the cytokine responses of CD...
Background: Tuberculosis is one of the world’s leading killers, stealing 1.4 million lives and causi...
Mice infected with fluorescent protein-expressing M. tuberculosis were injected with EdU and its inc...