Expression changes of COX-1, COX-2, and PGE₂ after rebamipide administration.

<p>(A-B) The mRNA expressions of COX-1 (A) and COX-2 (B) in the small intestine of the four groups were shown (n = 6, *<i>P</i> < 0.05 when compared with Con-Reb and Con-Sal groups; ^&<i>P</i> < 0.05 when compared with SII-Sal, Con-Reb, and Con-Sal groups). (C) Immunohistochemistry staining for COX-1 and COX-2 in small intestinal epithelium of the SII-Reb and SII-Sal groups was shown. COX-1 and COX-2 positive cells were detected in the subepithelial area (black arrowheads; bar indicates 25μm). (D) Protein levels of COX-1, COX-2, and PGE₂ indicated by Western blots analysis. (G-I) The integrated intensities of bands for COX-1, COX-2, and PGE₂ (n = 6, *<i>P</i> < 0.05 when compared with Con-Reb and Con-Sal groups; ^&<i>P</i> < 0.05 when compared with SII-Sal, Con-Reb, and Con-Sal groups). (H) The concentrations of PGE₂ in the small intestine of the four groups were shown (n = 6, *<i>P</i> < 0.05 when compared with Con-Reb and Con-Sal groups; ^&<i>P</i> < 0.05 when compared with SII-Sal, Con-Reb, and Con-Sal groups).